Borrowing Information Across Genes and Experiments for Improved Error Variance Estimation in Microarray Data Analysis
نویسندگان
چکیده
منابع مشابه
Borrowing information across genes and experiments for improved error variance estimation in microarray data analysis.
Statistical inference for microarray experiments usually involves the estimation of error variance for each gene. Because the sample size available for each gene is often low, the usual unbiased estimator of the error variance can be unreliable. Shrinkage methods, including empirical Bayes approaches that borrow information across genes to produce more stable estimates, have been developed in r...
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ژورنال
عنوان ژورنال: Statistical Applications in Genetics and Molecular Biology
سال: 2012
ISSN: 1544-6115
DOI: 10.1515/1544-6115.1806